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| Description | Residues 71–85 of M. tuberculosis CFP-10 (10-kDa culture filtrate protein, RD1-encoded with ESAT-6); a specific T-cell epitope used in T-SPOT/IGRA assays and TB vaccine research. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CFP10 (71-85) | CFP10 71-85, EsxB(71-85), Rv3874(71-85), M. tuberculosis 10-kDa culture filtrate protein 10 fragment | M. tuberculosis antigen peptide, T cell antigen, IGRA/ELISpot assay, Vaccine development | EISTNIRQAGVQYSR (H-Glu-Ile-Ser-Thr-Asn-Ile-Arg-Gln-Ala-Gly-Val-Gln-Tyr-Ser-Arg-OH, linear 15-mer) | C72H120N24O25 | 1720.89 | 1721.89 | Free acid (per published formula) | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CFP10-01 | powder, white to off-white | Store at -20°C or below, protected from light, dry and sealed. Per supplier data, the powder is stable for ~3 years at -20°C. | Store at 4°C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store frozen at -20°C, avoid repeated freeze-thaw cycles. | Hydrophilic peptide (enriched in E/D/Q/N/R), net charge +1, readily soluble in water or aqueous buffer. No Cys/Met/Trp, so no special oxidation or light-sensitivity concerns; aliquot and freeze after reconstitution to preserve activity. | powder stable for ~3 years at -20°C when kept dry and sealed; protect from moisture and light; no special antioxidant requirement. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CFP10-01 | A 15-mer peptide corresponding to residues 71-85 of M. tuberculosis CFP10 (EsxB/Rv3874, RD1 region); stimulates TB-specific CD4+/CD8+ T cells to produce IFN-γ, used for IGRA/ELISpot TB testing and vaccine research. | CFP10 (10-kDa culture filtrate protein, EsxB/Rv3874) is an early secreted antigen encoded in the RD1 region of M. tuberculosis. It forms a tight 1:1 heterodimer with ESAT-6 (EsxA), a complex restricted to the pathogenic M. tuberculosis complex and absent from BCG and most non-tuberculous mycobacteria. CFP10(71-85) (EISTNIRQAGVQYSR) is an immunodominant T-cell epitope fragment that elicits IFN-γ production and CTL activity from CD4+ and CD8+ T cells of individuals expressing a spectrum of MHC molecules. This peptide is widely used for TB-specific T-cell assays (IGRA/ELISpot), and for studies of TB pathogenesis and vaccine immunogenicity. | Tuberculosis diagnosis, IGRA/ELISpot assays, Vaccine development, Tuberculosis immunology | M. tuberculosis RD1-secreted CFP10/ESAT-6 complex; MHC-restricted T cell epitope |
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