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| Description | TPNQRQNVC with a C-terminal Cys (capable of dimerization/cyclization), binding MHC-I and recognized by TCRs; used for epitope-specific T-cell assays, tetramers and recognition studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| TPNQRQNVC | LRH-1 peptide; TPNQRQNVC; P2RX5 110-118; minor histocompatibility antigen LRH-1; HLA-B7-restricted CTL epitope | Minor histocompatibility antigen, LRH-1, P2RX5, HLA-B7, CTL epitope, graft-versus-leukemia, hematopoietic transplantation, CD8 T cell, cysteine-containing | H-Thr-Pro-Asn-Gln-Arg-Gln-Asn-Val-Cys-OH | C41H70N16O15S | 1058.49 | 1059.16 | 以供应商 COA 为准(合成肽多为 TFA 盐;含游离 Cys,必要时确认未氧化为胱氨酸/亚砜) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-LRH1-01 | White to off-white powder | -20 °C or below, sealed under inert atmosphere (argon/nitrogen), protected from light and dry; aliquot strongly recommended to prevent Cys oxidation and dimerization from repeated freeze-thaw. | 2–8 °C for short-term transport/storage (under argon protection) | The C-terminal Cys free thiol is highly prone to oxidation into dimers/disulfide bonds; avoid air exposure in solution. Prepare fresh, flush with argon/nitrogen or add a small amount of reducing agent (e.g., DTT/TCEP, as required by the assay); store working aliquots at -20 °C under inert atmosphere. Strongly polar; soluble in water/buffer. | Stable as powder under inert atmosphere, protected from light and dry; repeated opening and air exposure accelerates Cys oxidation. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-LRH1-01 | 9-mer from minor histocompatibility antigen LRH-1, an HLA-B*0702-restricted CTL epitope associated with the graft-versus-leukemia (GVL) effect after allogeneic hematopoietic transplantation. | TPNQRQNVC is the HLA-B*0702-restricted 9-mer epitope of the minor histocompatibility antigen (MiHA) LRH-1, derived from an aberrant open reading frame produced by a frameshift polymorphism in the P2X purinoceptor 5 (P2RX5) gene. The CTL clone RP1 specifically recognizes this peptide in the HLA-B7 context and can mediate the graft-versus-leukemia (GVL) effect after allogeneic hematopoietic stem cell transplantation, associated with remission of chronic myeloid leukemia (CML). This antigen is aberrantly expressed on hematopoietic cells and some solid tumors, and is a classic tool peptide for MiHA-specific adoptive T-cell therapy research. | Transplantation immunology; minor histocompatibility antigens; graft-versus-leukemia (GVL); allogeneic hematopoietic stem cell transplantation; MiHA-specific T cells; tumor immunology | HLA-B*0702 (MHC class I); CD8+ T-cell TCR (CTL RP1) |
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