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| Description | Tetanus toxin heavy-chain residues 830–844 (canonical QYIKANSKFIGITEL), a broadly MHC-II-restricted universal helper epitope; co-administered/conjugated to weak immunogens to boost antibody responses in hapten and peptide vaccines. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Tetanus Toxin (830-844) | TT830-844, P2 Th epitope, QYIKANSKFIGITEL, Tetanus toxin 830-844 [CAS 126779-13-3] | Tetanus toxin P2 epitope, promiscuous HLA-DR Th epitope, vaccine carrier | QYIKANSKFIGITEL (H-Gln-Tyr-Ile-Lys-Ala-Asn-Ser-Lys-Phe-Ile-Gly-Ile-Thr-Glu-Leu-OH, 15-aa linear, free base) | C80H129N19O23 | 1723.95 | 1725.02 | Free base (per published formula) | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TETX-01 | powder, white to off-white; generally reported as water-soluble by suppliers | Store desiccated and sealed below -20°C, protected from light; powder stable for 2-3 years; reconstituted aliquots at -80°C for ~1 year | Store sealed and desiccated at 4°C, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C, avoid repeated freeze-thaw | Classically water-soluble; dissolve directly in water or PBS; DMSO may be used as co-solvent if needed. Contains 1 Tyr (weak light sensitivity; protect from light); net charge +1 (2 Lys, 1 Glu); no Cys/Met/Trp, good oxidative stability | powder stable for 2-3 years at -20°C when desiccated and sealed; protect from moisture and light; after opening, aliquot promptly and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TETX-01 | The classic promiscuous HLA-DR-binding CD4+ T helper (Th) epitope QYIKANSKFIGITEL from tetanus toxin residues 830-844; binds multiple HLA-DRB molecules and is widely used in vaccine design to provide T-cell help and enhance antibody responses to conjugated B-cell epitopes/antigens. | This peptide corresponds to residues 830-844 (QYIKANSKFIGITEL) of tetanus toxin (TT), a well-characterized promiscuous HLA-DR-binding CD4+ T helper epitope presented by multiple HLA-DRB1 alleles and activating specific CD4+ T cells. Owing to its strong immunogenicity and broad HLA restriction, it is commonly conjugated or co-administered with B-cell epitopes, haptens or protein antigens to enhance antibody responses and immune memory in synthetic peptide vaccine, antitumor and anti-infective vaccine designs. It is also widely used as a model Th epitope in T-cell epitope mapping and vaccine adjuvant studies. | Vaccine design, immunology research, T-cell epitope identification, peptide vaccines, tumor immunology | HLA-DR (multiple HLA-DRB1 alleles, promiscuous); CD4+ T helper cells; tetanus-toxin-specific T-cell clones |
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