Shanghai Sonyt Biotechnology Co., Ltd. is one of the leading manufacturers and suppliers of cas 244049-41-0 muc5ac基序肽;muc5acmotifpeptide in China, also supports custom service. Welcome to wholesale bulk high quality cas 244049-41-0 muc5ac基序肽;muc5acmotifpeptide from our factory. Contact us for more details.
| Description | The MUC5AC (secreted gel-forming mucin) VNTR motif; MUC5AC is the major goblet-cell airway mucin linked to mucus hypersecretion/asthma; used for mucin epitopes and mucosal immunity. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| MUC5AC motif peptide (human MUC5AC mucin tandem-repeat motif 16-mer GTTPSPVPTTSTTSAP) | MUC5AC motif peptide; GTTPSPVPTTSTTSAP; MUC5AC tandem repeat; GalNAc-T substrate peptide; CAS 244049-41-0 | Mucin MUC5AC, tandem repeat motif, O-glycosylation substrate, GalNAc-T (polypeptide GalNAc-transferase), Thr/Ser sites, respiratory mucus, glycosylation research, synthetic peptide | H-Gly-Thr-Thr-Pro-Ser-Pro-Val-Pro-Thr-Thr-Ser-Thr-Thr-Ser-Ala-Pro-OH (GTTPSPVPTTSTTSAP, linear 16-mer free acid). Mimics one repeat unit of the human MUC5AC mucin tandem repeat (TR) domain; rich in Thr x6 and Ser x3, it is a canonical synthetic substrate for UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (GalNAc-T1/T2/T3 etc.) that initiate O-glycosylation (Tn antigen, GalNAc alpha1-O-Ser/Thr); Pro x4 provides backbone flexibility and beta-turn character; free N-terminal amine and free C-terminal carboxyl; no Cys/Met/Trp/Tyr. | C63H104N16O26 | 1500.73 | 1501.61 | Free acid (matches supplier-published formula C63H104N16O26) | 16 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MUC5AC-01 | White to off-white powder (CAS 244049-41-0) | Store frozen below -20 C, dry and sealed; stable approx. 2-3 years as powder | Store at 2-8 C sealed and dry, use within 2-4 weeks; after reconstitution aliquot and store at -20 C | Good water solubility (hydroxylated Thr x6 / Ser x3, only one hydrophobic Val); reconstitute directly in sterile water or neutral buffer; no Met (no oxidation), no Cys (no oxidation/disulfide), no Trp/Tyr (no photolability); after reconstitution, aliquot and freeze to avoid repeated freeze-thaw | powder stable long-term (~2-3 years) at -20 C, dry and sealed; no Met/Trp so low oxidation/photodegradation risk; mainly keep moisture-proof |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-MUC5AC-01 | MUC5AC motif peptide (GTTPSPVPTTSTTSAP, CAS 244049-41-0) is a 16-mer mimicking the human MUC5AC mucin tandem-repeat unit, rich in Thr/Ser O-glycosylation sites and used as a canonical substrate to study the acceptor specificity of polypeptide GalNAc-transferases and hierarchical O-glycosylation. | MUC5AC motif peptide (GTTPSPVPTTSTTSAP, CAS 244049-41-0) is a 16-residue synthetic peptide that faithfully reproduces one repeat unit of the central tandem repeat (TR) domain of human mucin 5AC (MUC5AC). MUC5AC is a major gel-forming mucin of airway, gastric and cervical mucus gels; its polypeptide backbone is densely modified by O-linked N-acetylgalactosamine (Tn antigen) initiated by the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T / GalNT) family, and further elongated by downstream glycosyltransferases into complex O-glycans. The peptide carries six Thr and three Ser residues with a Pro-rich (x4) backbone and was the model substrate used by Tetaert et al. (2001) to compare the acceptor-site specificities of the three major isoforms GalNT1, GalNT2 and GalNT3: after in vitro transfer reactions, products were separated by capillary electrophoresis, the number of incorporated GalNAc residues was determined by MALDI-TOF MS and the sites located by Edman degradation. A maximum of three GalNAc residues could be transferred onto the peptide; Thr clusters proved essential for backbone recognition, supporting the view that different GalNT isoforms O-glycosylate mucin backbones in a hierarchical order. It is widely used to study O-glycosylation mechanisms, glycosyltransferase substrate mapping, aberrant tumor O-glycans (Tn/sTn), and respiratory mucin secretion and mucociliary clearance. | O-glycosylation mechanisms, ppGalNAc-T/GalNT enzymology, MUC5AC structure and function, respiratory/gastric mucus biology, Tn antigen and tumor-associated glycosylation, glycoproteomics | Polypeptide N-acetylgalactosaminyltransferases ppGalNAc-T1/T2/T3 family; MUC5AC tandem-repeat backbone; Thr/Ser O-glycosylation sites |
Hot Tags: cas 244049-41-0 muc5ac基序肽;muc5acmotifpeptide, China cas 244049-41-0 muc5ac基序肽;muc5acmotifpeptide manufacturers, suppliers, factory, 124454-83-7, 125366-42-9, Ac MBP 1 11 , CAS 199727 68 9, CAS 2293841 58 2, CEF4
