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| Description | The 20-mer IRGRILHDGAYSLTLQGLGIH used as a long-peptide epitope for in-vivo CD4+/CD8+ immunity, cross-presentation and long-peptide vaccines; used for epitope mapping and T-cell assays. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| IRGRILHDGAYSLTLQGLGIH (rat HER2/neu class II MHC multi-epitope peptide) | IRGRILHDGAYSLTLQGLGIH, rat HER2/neu class II peptide, class II HER2-DC1 vaccine peptide | T-cell epitope, MHC class II, CD4 T cell, cancer vaccine, HER2 immunotherapy, dendritic cell vaccine | IRGRILHDGAYSLTLQGLGIH (H-Ile-Arg-Gly-Arg-Ile-Leu-His-Asp-Gly-Ala-Tyr-Ser-Leu-Thr-Leu-Gln-Gly-Leu-Gly-Ile-His-OH, linear 21-mer, free N-terminal amino / free C-terminal carboxyl) | C102H168N32O28 | 2289.27 | 2290.65 | Free acid (per published formula) | 21 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-HER2II-01 | white to off-white (MCE, purity ≥95% HPLC) | Store frozen below -20 C, protected from light, dry and tightly sealed | Store at 4 C sealed, dry and light-protected, use within 2-4 weeks; after reconstitution aliquot and store at -20 C, avoid repeated freeze-thaw | Moderately soluble in water (21-mer, ~38% hydrophobic); contains 1 Tyr (light-sensitive), no Cys/Met; reconstitute in sterile water or PBS with sonication if needed; protect from light and aliquot for storage | powder stable long-term at -20 C when dry, light-protected and sealed; keep moisture- and light-protected |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-HER2II-01 | A multi-epitope MHC class II peptide derived from rat HER2/neu, used in HER2-DC1 dendritic-cell cancer-vaccine and CD4 T-cell studies. | IRGRILHDGAYSLTLQGLGIH is a multi-epitope MHC class II (CD4) peptide derived from the rat HER2/neu oncoprotein. It is loaded onto dendritic cells (DC1) to generate HER2 vaccines, eliciting CD4 T-cell responses in HER2-positive mammary carcinoma models and synergizing with sequential anti-PD-1 therapy to improve survival. It is used in tumor immunotherapy and epitope-vaccine design. | Tumor immunology, cancer vaccine, dendritic cell vaccine, MHC class II epitope, HER2-targeted therapy, immunotherapy | MHC class II (CD4 T-cell recognition; rat HER2/neu) |
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