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| Description | The IRBP-derived R16 peptide induces experimental autoimmune uveitis (EAU) by activating retina-specific CD4+ T cells; a classic model for autoimmune intraocular inflammation and Th17 tolerance. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| IRBP derived peptide, R16 | IRBP R16, Interphotoreceptor retinoid-binding protein peptide (aa 1177-1191), RBP3-derived peptide | Autoimmune uveitis, EAU model induction peptide, Retinal autoantigen peptide, Ophthalmology research | ADGSSWEGVGVVPDV (H-Ala-Asp-Gly-Ser-Ser-Trp-Glu-Gly-Val-Gly-Val-Val-Pro-Asp-Val-OH, linear 15-mer) | C64H96N16O24 | 1472.68 | 1473.56 | Free acid | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-IRBPR16-01 | powder, white to off-white | Store at -20°C or below, protected from light, dry and sealed. Contains a tryptophan residue; strict light protection is required. | Store at 4°C sealed, dry and dark, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C protected from light. | Hydrophilic peptide (enriched in D/E/S/G), net charge -3, good water solubility. Contains one Trp residue that is light-sensitive and prone to photo-oxidation; protect from light during dissolution and storage, use promptly, and consider degassed handling. | powder is long-term stable at -20°C when dry, sealed and dark. Because of the Trp residue, protect from moisture and light; amber vial or nitrogen blanketing recommended. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-IRBPR16-01 | A 15-mer peptide derived from interphotoreceptor retinoid-binding protein (IRBP/RBP3), ADGSSWEGVGVVPDV (aa 1177-1191), which induces experimental autoimmune uveitis (EAU) in susceptible animal strains for uveitis modeling. | R16 is a 15-mer peptide derived from interphotoreceptor retinoid-binding protein (IRBP/RBP3), corresponding to approximately residues 1177-1191 of human/bovine IRBP. IRBP is a photoreceptor-cell protein located in the interphotoreceptor matrix between retinal photoreceptors and the retinal pigment epithelium. R16 is a well-established uveitogenic epitope: emulsified in complete Freund's adjuvant (CFA) and used to immunize susceptible strains such as Lewis rats, it efficiently induces experimental autoimmune uveitis (EAU). This peptide is widely used to study autoimmune uveitis pathogenesis, the blood-retinal barrier, and anti-inflammatory drug evaluation. Note: R16 (ADGSSWEGVGVVPDV) is a distinct sequence from the commonly cited IRBP1-20 (GPTHLFQPSLVLDMAKVLLD); the two should not be confused. | Autoimmune uveitis, EAU animal models, Retinal immunology, Ophthalmic drug evaluation | Retinal autoantigen IRBP/RBP3; autoreactive T cell-mediated EAU |
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