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| Description | An engineered version of the tetanus-toxoid P2 helper epitope (830-843), retaining broad HLA-DR CD4+ recognition; used as a universal helper/carrier to boost hapten or weak-antigen responses. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| TET 830 Modified Peptide (Tetanus Toxoid Universal T-helper Epitope, A16L) | TET830 modified peptide / universal Th epitope / T-helper antigen A16L / tetanus toxin 830-844 peptide | T-helper epitope, universal Th epitope, vaccine adjuvant, CD4+ epitope, HLA-DR restricted | H-Ala-Gln-Tyr-Ile-Lys-Ala-Asn-Ser-Lys-Phe-Ile-Gly-Ile-Thr-Glu-Leu-OH; derived from tetanus toxin (Clostridium tetani neurotoxin, UniProt P04958) residues 830-844. Native fragment QYIKANSKFIGITEL; this modified version adds N-terminal Ala (A16L) yielding AQYIKANSKFIGITEL, a promiscuous HLA-DR-restricted CD4+ helper epitope. | C83H134N20O24 | 1794.99 | 1796.1 | Free peptide | 16 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-TET830-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light, ~24 months | 2-8°C sealed, desiccated, ~2-4 weeks | Hydrophilic polar peptide; readily soluble in water/PBS. Prepare fresh; aliquot and store at -20°C, avoid repeated freeze-thaw | Contains 1 Tyr: protect from light to prevent photo-oxidation; no Cys/Met/Trp. Stable when desiccated and sealed |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-TET830-01 | Tetanus toxoid universal Th epitope, built-in CD4+ T-cell help / vaccine adjuvant peptide | A 16-mer promiscuous human CD4+ T-helper epitope derived from tetanus toxoid (Clostridium tetani neurotoxin residues 830-844, UniProt P04958). Native fragment QYIKANSKFIGITEL; this modified version adds N-terminal Ala (A16L) yielding AQYIKANSKFIGITEL, a universal HLA-DR-restricted helper epitope. Used as built-in T-cell help in multipeptide melanoma and advanced ovarian cancer vaccine trials (Slingluff gp100 + tetanus helper peptide, Clin Cancer Res 2001) and widely applied to boost CD4+ help in DNA/peptide/DC vaccine formulations. | Immunology, vaccine development, T-cell epitope, tumor immunology, helper T cells | HLA-DR (MHC-II, promiscuous) |
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