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| Description | gp100 residues 209–217 (wild-type ITDQVPFSV; clinical 210M analogue IMDQVPFSV), an HLA-A*0201-restricted classic epitope for melanoma ACT and vaccines; used for anti-tumor CTL studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GP100 (209-217) peptide | gp100 epitope peptide 209-217, ITDQVPFSV, Melanoma-associated antigen gp100 pmel-17 (209-217), natural HLA-A2-restricted epitope, CAS 162558-10-3 | Melanoma tumor antigen, HLA-A2-restricted epitope, Cytotoxic T lymphocyte (CTL), Tumor immunotherapy, Cancer vaccine | ITDQVPFSV (H-Ile-Thr-Asp-Gln-Val-Pro-Phe-Ser-Val-OH, linear 9-mer, wild-type natural sequence; NOT the 2M high-affinity variant IMDQVPFSV) | C46H72N10O15 | 1004.52 | 1005.14 | Free acid (neutral peptide per published formula, BroadPharm CAS 162558-10-3) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GP100-01 | powder, white to off-white (purity >=95% HPLC; CAS 162558-10-3) | Store frozen below -20 C, protected from light, dry and tightly sealed (stable approx. 2-3 years as powder) | Store at 4 C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store at -20 C | Hydrophobic epitope peptide (hydrophobic residues 56%, net charge -1); poor water solubility. Pre-dissolve in a small volume of DMSO, then dilute with sterile water or buffer (e.g. PBS) to working concentration. Prone to aggregation; avoid vigorous vortexing after reconstitution, use promptly, and aliquot to minimize repeated freeze-thaw | powder stable long-term (approx. 2-3 years) at -20 C, dry, light-protected and sealed; keep moisture-proof; contains no Cys/Met/Trp, so no oxidation/light-sensitive residues and good stability, but avoid prolonged humid air exposure |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GP100-01 | gp100 (209-217) (ITDQVPFSV), a natural HLA-A2.1-restricted CD8+ T cell epitope derived from melanoma differentiation antigen gp100/pmel-17, for tumor-specific CTL recognition and melanoma immunity/vaccine research. | This is the wild-type natural epitope ITDQVPFSV (CAS 162558-10-3) spanning residues 209-217 of the melanoma differentiation antigen gp100 (pmel-17/SILV). This 9-mer is presented by HLA-A*0201 and recognized by tumor-specific cytotoxic T lymphocytes (CTLs), and is a canonical natural epitope in melanoma adoptive T-cell therapy and cancer vaccine research. Note: the more widely used clinical variant is the Thr2-to-Met high-affinity analog gp100:209-2M (IMDQVPFSV, which raises HLA-A2 binding); this product is the wild-type sequence ITDQVPFSV (formula contains no sulfur, clearly distinct from the 2M variant C47H74N10O14S / 1035.3). Used for HLA-A2 presentation analysis, CTL epitope mapping, peptide-MHC tetramer production and tumor immunology studies. | Tumor immunology, Melanoma, HLA-A2-restricted epitopes, CTL responses, Cancer vaccines | HLA-A*0201 (MHC-I); gp100/pmel-17-specific CD8+ T cell receptor (TCR) |
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