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| Description | CLIP residues 86–100 (free salt form), occupying the MHC-II groove until replaced by antigen peptide; used for MHC-II loading, HLA-DM-mediated exchange and exogenous presentation. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CLIP (86-100) (CAS:648881-58-7) (class II-associated invariant chain peptide 86-100, free base/acetate) | CLIP 86-100 acetate; PVSKMRMATPLLMQA; MHC-II placeholder peptide; invariant chain peptide; BioCat TP1573L; PEP-CLIP86-01 | MHC-II antigen presentation, CLIP invariant chain peptide, HLA-DM peptide exchange, CD74/invariant chain, MHC-II peptide loading, acetate form, amphipathic (anti-aggregation), Met x3 (anti-oxidation) | Linear 15-mer, H-Pro-Val-Ser-Lys-Met-Arg-Met-Ala-Thr-Pro-Leu-Leu-Met-Gln-Ala-OH (PVSKMRMATPLLMQA); residues 86-100 of the human invariant chain CD74 (MHC-II gamma chain) Ii 81-104 segment LPKPPKPVSKMRMATPLLMQALPM (some suppliers number it 87-101, identical sequence); C-terminal free acid; CAS 648881-58-7 (same sequence as CLIP 86-100 TFA salt, different salt form) | C72H128N20O19S3 | 1672.88 | 1674.12 | Free base / acetate (CAS 648881-58-7 corresponds to free base; BioCat lists CLIP 86-100 acetate) | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CLIP86-01 | White to off-white powder (free base/acetate form; CAS 648881-58-7, e.g. BioCat TP1573L; amphipathic synthetic peptide containing three methionines) | Store sealed, dry and frozen at or below −20°C; the acetate form is less hygroscopic than the TFA salt, but still keep dry and sealed and aliquot; three Met residues are oxidation-sensitive; avoid repeated freeze-thaw cycles. | Short-term storage at 2–8°C sealed and dry for about 2 weeks; aliquot working solutions and store at −20°C, prepare fresh, avoid repeated freeze-thaw. | Amphipathic peptide (Lys/Arg hydrophilic and Leu/Met hydrophobic segments); the acetate form dissolves near-neutral in water, and it is soluble in water or pH 7.4 PBS, with a small amount of DMSO as co-solvent if needed; amphipathic peptides aggregate at high concentration, so prepare low-concentration (≤1–2 mg/mL) working solutions in small aliquots. Three Met residues can oxidize to Met(O) in solution - avoid oxidants and prolonged room-temperature standing; use diluted solutions the same day. For in vitro MHC-II peptide-loading assays, co-incubate with purified class II molecules per the protocol. | acetate powder is stable for about 2 years at −20°C sealed and dry; the acetate form is less hygroscopic than the TFA salt, and Met oxidation is the main degradation risk - protect from oxidants and moisture; weigh promptly after opening and reseal. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CLIP86-01 | Human invariant chain (CD74)-derived CLIP 86-100 peptide (PVSKMRMATPLLMQA, 15-mer, free base/acetate, CAS 648881-58-7), the natural placeholder peptide in the MHC-II antigen-binding groove; a core tool peptide for MHC-II assembly/trafficking, HLA-DM peptide exchange and autoimmunity research. | CLIP (class II-associated invariant chain peptide) is derived from residues 81–104 of the human invariant chain Ii/CD74 (MHC-II gamma chain), segment LPKPPKPVSKMRMATPLLMQALPM; residues 86–100, PVSKMRMATPLLMQA, form the core sequence occupying the MHC-II antigen-binding groove (some suppliers number it 87-101, identical sequence). During MHC-II assembly in the ER/endosomes, CLIP acts as a placeholder that prevents premature binding of self-peptides and ensures proper folding and trafficking; in endosomes/lysosomes, the catalytic factor HLA-DM (mouse H-2M) binds MHC-II and catalyzes the replacement of CLIP by exogenous antigenic peptides - this CLIP-release/peptide-loading process is the rate-limiting step of antigen-specific CD4+ T-cell responses. This chemically synthesized CLIP(86-100) linear peptide (free base/acetate, CAS 648881-58-7) is widely used as: a standard placeholder/control peptide for in vitro MHC-II refolding and peptide loading; a substrate for studying HLA-DM-mediated peptide-exchange kinetics; a tool to detect cell-surface MHC-II/CLIP complexes (anti-CLIP antibodies) and the antigen-presentation capacity of B cells/dendritic cells; and a reference peptide for studying aberrant MHC-II presentation in autoimmune disease. The acetate form reconstitutes more gently in neutral buffers and is preferable for TFA-sensitive cell assays; because it contains three Met residues, protect it from Met oxidation during experiments and storage. |
MHC-II antigen presentation, HLA-DM peptide exchange, invariant chain/CD74, in vitro MHC-II refolding & peptide loading, autoimmunity research | MHC-II antigen-binding groove; HLA-DM (mouse H-2M) |
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