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| Description | BACE1 (β-site APP cleaving enzyme 1, the Aβ rate-limiting enzyme) residues 485–501, mostly the intracellular C-tail; used for BACE1 phosphorylation/trafficking, epitope antibodies and Aβ-generation studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BACE1 (485-501) | BACE1 C-terminal 485-501 peptide, beta-secretase 1 cytoplasmic tail peptide, BACE1 485-501 synthetic peptide (CAS 300584-87-6) | BACE1 C-terminal peptide, immunogen, polyclonal antibody production, Alzheimer's disease research | CLRQQHDDFADDISLLK (H-Cys-Leu-Arg-Gln-Gln-His-Asp-Asp-Phe-Ala-Asp-Asp-Ile-Ser-Leu-Leu-Lys-OH, linear 17-mer) | C86H137N25O29S | 2015.97 | 2017.25 | Free acid | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BACE1-01 | powder, white to off-white | Store frozen below -20 C, protected from light, dry and tightly sealed; after reconstitution, aliquot working solutions and store at -80 C | Store at 4 C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store at -20 C | Hydrophilic peptide (net charge ~ -1, with 4x Asp plus Arg/Lys/His and 2x Gln) with good water solubility; reconstitute in water or neutral buffer. Contains one free N-terminal Cys whose thiol oxidizes readily to a disulfide dimer: keep solutions oxygen-free, avoid oxidizing agents, use fresh or aliquot under nitrogen and freeze; Phe-containing, otherwise stable; protect from light and moisture. | powder is stable long-term at -20 C when dry and sealed; keep moisture-proof and light-protected; free Cys-containing - store dry and oxygen-free to prevent dimerization |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BACE1-01 | A synthetic peptide spanning residues 485-501 of the C-terminal cytoplasmic tail of human beta-secretase 1 (BACE1, incl. Cys485), commonly KLH-conjugated as an immunogen to raise BACE1 polyclonal antibodies for Alzheimer's disease and A-beta metabolism research. | This synthetic peptide corresponds to residues 485-501 of the C-terminal cytoplasmic tail of human BACE1 (beta-site APP cleaving enzyme 1, UniProt P56817; sequence CLRQQHDDFADDISLLK, with a free Cys485). BACE1 is the key aspartic protease that cleaves the amyloid precursor protein (APP) to generate beta-amyloid peptides, and is a central drug target in Alzheimer's disease (AD). KLH-conjugated, the peptide is widely used as an immunogen to generate BACE1 C-terminal-specific polyclonal antibodies (e.g. Invitrogen PEP-093, Millipore EMD Bio-195111, Abcam ab10716) and for antibody specificity verification, peptide-competition blocking controls, and BACE1 expression detection in AD research. Note: one supplier (Phoenix Biotech) lists MW 1997.96, which does not match residue-by-residue calculation; the benchmark in this table is used. | Neuroscience, Alzheimer's disease, BACE1 polyclonal antibody production, A-beta metabolism research | BACE1 (beta-secretase 1) C-terminal cytoplasmic tail; beta-secretase activity |
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