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| Description | β-cell autoantigen IGRP (islet-specific G6PC-related protein) residues 206–214, an immunodominant epitope recognized by pathogenic CD8+ T cells (e.g. clone 8.3) in NOD mice; used in type-1-diabetes autoimmunity. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| IGRP (206-214) / G6PC2 (206-214), H-2Kd-restricted CD8 autoantigen epitope peptide (VYLKTNVFL) | IGRP206-214, VYLKTNVFL, G6PC2 (206-214), NRP-V7-related H-2Kd epitope | T-cell epitope, MHC class I, CD8 T cell, autoantigen, type 1 diabetes, NOD mouse, islet autoimmunity | VYLKTNVFL (H-Val-Tyr-Leu-Lys-Thr-Asn-Val-Phe-Leu-OH, linear 9-mer, free N-terminal amino / free C-terminal carboxyl) | C54H85N11O13 | 1095.63 | 1096.33 | Free acid (per published formula) | 9 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-IGRP-01 | white to off-white (BroadPharm/CPC Scientific, purity ≥95% HPLC) | Store frozen below -20 C, protected from light, dry and tightly sealed | Store at 4 C sealed, dry and light-protected, use within 2-4 weeks; after reconstitution aliquot and store at -20 C, avoid repeated freeze-thaw | Moderately soluble in water (~56% hydrophobic); contains 1 Tyr (light-sensitive), no Cys/Met; dissolve in a small amount of DMSO then dilute with water/PBS to working concentration; protect from light | powder stable long-term at -20 C when dry, light-protected and sealed; keep moisture- and light-protected |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-IGRP-01 | A 9-mer H-2Kd-restricted CD8 autoantigen epitope from murine IGRP/G6PC2 residues 206-214, the core diabetogenic epitope in the NOD mouse model of type 1 diabetes. | IGRP(206-214), sequence VYLKTNVFL, spans residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP/G6PC2) and is presented by H-2Kd. It is a dominant CD8+ T-cell autoantigen in the NOD mouse model of type 1 diabetes, driving beta-cell-specific cytotoxicity and disease; the 8.3 TCR-transgenic mouse T cells are specific for this epitope. Its mimotope is NRP-V7. | Type 1 diabetes, autoimmunity, CD8 T cell, NOD mouse, islet autoantigen, MHC class I epitope | H-2Kd (mouse MHC class I) |
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