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| Description | The synthetic epitope CKS-17 binds the corresponding MHC and is recognized by T cells; used for epitope-specific T-cell assays, recognition mechanisms and vaccine-epitope research. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| CKS-17 (Retroviral p15E-derived 17-mer immunosuppressive peptide) | CKS-17; p15E immunosuppressive domain peptide; Cianciolo peptide | immunosuppressive peptide,retrovirus,p15E transmembrane protein,viral immune evasion,immunomodulation,cAMP induction | Linear free-acid 17-mer LQNRRGLDLLFLKEGGL (N-term H / C-term OH) | C87H148N26O24 | 1941.12 | 1942.29 | TFA salt (per supplier CoA) | 17 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-CKS17-01 | White to off-white powder | Store at -20°C or below, protected from light, dry and sealed; stable for 2-3 years | Store at 2-8°C, protected from light and moisture, for 2-4 weeks | Highly hydrophobic and poorly water-soluble; first dissolve in a small volume of anhydrous DMSO or DMF until clear, then dilute with water or buffer to working concentration. Prepare fresh; avoid repeated freeze-thaw cycles | powder is stable but hygroscopic; equilibrate to room temperature in a desiccator before weighing, then keep sealed |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-CKS17-01 | A 17-mer immunosuppressive peptide derived from the retroviral transmembrane protein p15E; inhibits T-cell proliferation and cytokine production and induces cAMP, used in viral immune-evasion and immunomodulation research. | CKS-17 is a highly conserved 17-amino-acid peptide (LQNRRGLDLLFLKEGGL) located within the transmembrane envelope protein p15E (TM) of murine leukemia virus (MLV) and related retroviruses such as HIV, originally identified by Cianciolo et al. in 1985. It exerts potent immunosuppressive activity, inhibiting T-lymphocyte proliferation, mixed lymphocyte reactions and IL-2/cytokine production, and elevates cAMP in vitro. It serves as a key molecular model of retroviral immune evasion and is widely used to study retrovirus-associated immunosuppression, tumor escape and immunomodulatory signaling, as a pharmacological tool peptide for the p15E/retroviral membrane immunosuppressive domain. | Tumor immunology,retrovirology,viral immune evasion,immunomodulation,autoimmunity and inflammation research | Conserved immunosuppressive domain of retroviral p15E transmembrane protein; T-cell proliferation/cytokine signaling; adenylate cyclase-cAMP pathway |
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