![CAS 98474-60-3 Des-[Gly77,His78]MyelinBasicProtein(68-84),bovine](/uploads/48442/cas-98474-60-3-des-gly77-his785e896.jpg)
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| Description | Bovine MBP residues 68–84 lacking Gly77/His78, used to probe key encephalitogenic residues, TCR recognition and immunomodulation; a classic engineered peptide for EAE/MS epitope structure-function studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Des-[Gly77,His78] Myelin Basic Protein (68-84), bovine | des-Gly77,des-His78 MBP(68-84) bovine; YGSLPQKAQRPQDEN | MBP, myelin, EAE, autoimmunity, demyelination, 15-mer peptide | H-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ala-Gln-Arg-Pro-Gln-Asp-Glu-Asn-OH | C73H115N23O26 | 1729.84 | 1730.85 | 以供应商COA为准(常用TFA盐或醋酸盐) | 15 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MBPDEL-01 | White to off-white powder | -20 °C or -80 °C, dry, protected from light, sealed storage; avoid repeated freeze-thaw. | 2–8 °C short-term; aliquot and freeze working solutions. | Contains Tyr (position 1); protect from light. No Cys/Met. Rich in polar residues (K/Q/N/D/E/R/S), good water solubility; soluble in water/buffer. Long-term standing in liquid leads to wall adsorption or aggregation. | Stable as powder under dry, sealed, light-protected conditions. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Receptors |
| PEP-MBPDEL-01 | 15-mer from bovine myelin basic protein (MBP) residues 68–84 with deletion of Gly77/His78, for EAE experimental autoimmune encephalomyelitis and demyelinating-disease studies. | The original 17-mer of bovine myelin basic protein (MBP) residues 68–84 is YGSLPQKAQGHRPQDEN; natural deletion of Gly77 and His78 yields the 15-mer YGSLPQKAQRPQDEN. This region is an immunodominant/encephalitogenic site of MBP, used for induction of the experimental autoimmune encephalomyelitis (EAE) model, studies of T-cell proliferation and cytokine responses in demyelinating diseases (multiple sclerosis, MS), and investigations of autoimmune mechanisms and neuroimmunology. | Multiple sclerosis; EAE model; myelin basic protein; autoimmunity; neuroimmunology | MHC class II (recognized by CD4+ T cells) |
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