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| Description | Gliadin residues 31–43 (LQLQPFPQPQLPY), a key celiac-disease peptide driving innate/epithelial stress independent of tTG deamidation; TFA salt for celiac pathogenesis studies. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Gliadin p31-43 TFA | α-Gliadin p31-43, Gliadin toxic peptide p31-43, LGQQQPFPPQQPY (TFA salt) | Celiac disease, Gliadin peptide, Innate immune activation, Intestinal epithelium research | LGQQQPFPPQQPY (H-Leu-Gly-Gln-Gln-Gln-Pro-Phe-Pro-Pro-Gln-Gln-Pro-Tyr-OH, linear 13-mer, TFA salt) | C71H102N18O20 | 1526.75 | 1527.70 | TFA salt | 13 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GLIADIN-01 | powder, white to off-white | Store at -20°C or below, dry, sealed and protected from light. The TFA salt powder must be kept moisture-proof. | Store at 4°C sealed and dry, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C, avoid repeated freeze-thaw cycles. | Hydrophobic peptide (Leu/Phe, Pro-rich x4), poorly water-soluble. First dissolve in DMSO or acetonitrile to aid solubilization, then dilute with aqueous buffer to the desired concentration; gentle heating may help. No Met/Cys/Trp/Tyr oxidation-sensitive residues; use promptly after reconstitution. | powder is long-term stable at -20°C when dry and sealed. The TFA salt is hygroscopic; keep strictly moisture-proof, sealed and protected from light. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GLIADIN-01 | A 13-mer peptide corresponding to residues 31-43 of α-gliadin (LGQQQPFPPQQPY), the best-characterized cytotoxic/innate-immunogenic gliadin peptide in celiac disease research, supplied as the TFA salt. | Gliadin p31-43 (LGQQQPFPPQQPY) is a 13-mer peptide derived from residues 31-43 of α-/α2-gliadin (UniProt Q9ZP09), located upstream of the toxic 33-mer region in celiac disease. As an incompletely digested gliadin peptide, it induces innate immune responses in intestinal epithelial cells, interferes with endocytic/vesicular trafficking, and inhibits CFTR (by binding its NBD1 domain and reducing ATPase activity). Unlike the CD4+/HLA-DQ2/DQ8-dependent adaptive 33-mer, p31-43 primarily drives innate immune stress and epithelial toxicity, making it a classic tool peptide for studying celiac pathogenesis and gluten-free-diet alternatives. | Celiac disease, Gliadin toxicity mechanisms, Intestinal epithelial innate immunity, Gluten-related disorders | Intestinal epithelial endocytic/vesicular trafficking; CFTR (NBD1 domain); Innate immune stress pathways |
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