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| Description | Covers residues 25–53 of human GAP (the proGnRH C-terminal peptide), involved in the hypothalamic-pituitary-gonadal axis and prolactin regulation; used in neuroendocrine and reproductive physiology. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| GnRH Associated Peptide (25-53), human | hGAP 25-53, GnRH-Associated Peptide 25-53, FECTTHQPRSPLRDLKGALESLIEEETGQ, CAS 106061-19-2 | GnRH prohormone processing peptide, GAP, Neuroendocrine research, Immunogen, Antiserum production, RIA antigen | FECTTHQPRSPLRDLKGALESLIEEETGQ (H-Phe-Glu-Cys-Thr-Thr-His-Gln-Pro-Arg-Ser-Pro-Leu-Arg-Asp-Leu-Lys-Gly-Ala-Leu-Glu-Ser-Leu-Ile-Glu-Glu-Glu-Thr-Gly-Gln-OH, linear 29-mer, free N/C termini, free acid) | C140H226N40O49S | 3283.61 | 3285.64 | Free acid | 29 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-GAP-01 | White to off-white powder | Store frozen below -20°C, protected from light, sealed and dry; contains a free cysteine - store with desiccant under inert atmosphere if possible; avoid repeated freeze-thaw cycles | Store sealed and dry at 4°C, use within 2-4 weeks; aliquot and store reconstituted solution at -20°C, use promptly | Hydrophilic peptide (~31% hydrophobic residues; net charge -2, acidic Glu-enriched) with good water solubility; reconstitute in water or buffer. Contains 1 free Cys thiol prone to oxidative dimerization - deoxygenate solutions, avoid oxidants, aliquot to minimize freeze-thaw; no Tyr/Trp | powder is stable sealed, dry and light-protected at -20°C; protect from moisture and oxidation |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-GAP-01 | Synthetic peptide of residues 25-53 of human GAP (GnRH-associated peptide, UniProt P01148 processing product), FECTTHQPRSPLRDLKGALESLIEEETGQ; used as an immunogen to raise GAP-specific antisera for GnRH prohormone RIA and neuroendocrine research | This is a synthetic 29-mer corresponding to residues 25-53 (precursor residues 61-89) of human GAP (GnRH-associated peptide, residues 37-92, 56 aa), the processing product of prepro-GnRH / Progonadoliberin-1 (UniProt P01148, gene GNRH1, 92 aa), sequence FECTTHQPRSPLRDLKGALESLIEEETGQ. GAP is linked to the GnRH decapeptide via a 3-residue processing site (GKR) and released together. The peptide serves as an immunogen to generate GAP-specific antisera (MC-1, MC-2, MC-3) for radioimmunoassay (RIA) of the LHRH/GnRH prohormone and neuroendocrine research (Culler MD et al., Brain Res Bull 1986;17(2):219-23, PMID 3533219). It is not an MHC epitope but a neuropeptide precursor-derived processing peptide. | Neuroendocrinology, GnRH/LH-RH prohormone research, RIA antiserum production, Reproductive endocrinology, Immunogen preparation | No natural cell-surface receptor; used as immunogen to elicit GAP-specific antibodies; GnRH prohormone processing product (GAP) |
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