HOXB78–25

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HOXB78–25
Details
Homeobox B7 residues 8-25 fragment;
Category: Transcription-factor-derived peptide / tumor-immune epitope.
Peptide Purity (HPLC) ≥95%
Structure Linear epitope peptide (HOXB7 8-25)
Solubility Water, DMSO cosolvent, PBS
Storage Powder, −20°C, dry, light-protected
Category
Epitope Peptides
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Description

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Description HOXB7 N-terminal residues 8–25; HOXB7 is overexpressed in many tumors and drives angiogenesis, used for T-cell epitope mapping.

 

Product Basic Information Table

 

Product Standard English Name Product Abbreviation / Alias Function Tags (comma-separated) Core Structure Molecular Formula Exact Mass (Da) Average MW (Da) Salt Form Length (aa)
Homeobox protein Hox-B7 (HOXB7) residues 8-25, human HOXB7 (8-25), NTLFSKYPASSSVFATGA, UniProt P09629 N-terminal peptide, homeobox transcription factor N-terminal fragment HOXB7, homeobox transcription factor, embryonic development, tumor-associated antigen, HLA epitope, breast/ovarian cancer H-Asn-Thr-Leu-Phe-Ser-Lys-Tyr-Pro-Ala-Ser-Ser-Ser-Val-Phe-Ala-Thr-Gly-Ala-OH (18-aa linear peptide, free N-term/C-term; human HOXB7 (UniProt P09629) residues 8-25; no Cys/Met/Trp; 1 Tyr, 1 Lys; net charge +1) C84H126N20O27 1846.91 1848.05 TFA salt (typical) 18

 

Physicochemical Solubility & Storage Parameters

 

Product Code Appearance Long-term Storage Short-term Storage Solution Stability Solid Powder Stability
PEP-HOXB7-01 White to off-white powder (standard synthetic peptide) Store frozen below -20°C, dry, sealed and protected from light (2-3 years); contains 1 Tyr - keep moderately protected from light; TFA salt is hygroscopic - keep dry and sealed; avoid repeated freeze-thaw Store sealed, dry and protected from light at 2-8°C, use within 2-4 weeks; after reconstitution, aliquot and store at -20°C Net charge +1 (1 Lys, no acidic residues) with multiple polar Ser/Thr residues - relatively hydrophilic, soluble in water or dilute acetic acid / neutral buffer; contains 1 Tyr (light-sensitive) - protect from light; if needed, pre-wet with a small amount of DMSO then dilute with buffer powder stable for 2-3 years at -20°C when dry, sealed and protected from light; TFA salt is hygroscopic - store in a desiccator; aliquot promptly after opening

 

Functional Description

 

Product Code Frontend Short Summary Detailed Biological Function Description Applicable Research Areas (comma-separated) Targets / Pathways
PEP-HOXB7-01 18-aa peptide corresponding to human homeobox transcription factor HOXB7 (UniProt P09629) residues 8-25 (sequence NTLFSKYPASSSVFATGA), an N-terminal non-homeodomain fragment; used in HOXB7 tumor-associated antigen / HLA epitope and developmental transcriptional-regulation studies. HOXB7 (homeobox protein Hox-B7, UniProt P09629) is a sequence-specific transcription factor of the Antp homeobox family, critical for embryonic anterior-posterior patterning, organ development and hematopoiesis; it is aberrantly overexpressed in breast, ovarian and melanoma and other tumors, promoting proliferation, angiogenesis and invasion, and is regarded as a candidate tumor-associated antigen / HLA-restricted epitope. This product is residues 8-25 (NTLFSKYPASSSVFATGA) of the 217-aa human HOXB7 chain (N-terminus MSSLYYA…), lying in the N-terminal non-homeodomain region (the homeobox DNA-binding domain is at 137-196). It is used for prediction and validation of HOXB7-derived HLA epitopes, tumor immune-peptide library screening, antibody/reagent development, and studies of HOXB7 N-terminal interactions. Sequence basis: UniProt P09629 full-length human HOXB7; residues 8-25 agree with the TargetMol catalog (NTLFSKYPASSSVFATGA). Note: some suppliers (Amerigo / NovoPro) list a 15-mer PLLLKLLKSVGAQKD that does not match the P09629 human sequence; this product follows UniProt P09629 numbering. Tumor immunology, HLA epitope prediction/validation, embryonic development, homeobox transcription factor, breast/ovarian/melanoma research, peptide library screening HOXB7 protein (UniProt P09629); HLA-I/II presentation; PBX1 interaction

 

 

 

 

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