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| Description | The mature-region antigenic epitope of BMP-2 (residues 73–92); used to generate BMP-2-specific antibodies, assay recombinant BMP-2 immunogenicity and study antigen recognition in bone formation. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| BMP-2 Epitope (73-92) | BMP-2 73-92, knuckle epitope peptide, KIPKASSVPTELSAISTLYL, CAS 500719-13-1 | BMP-2 epitope peptide, Osteogenic mimetic peptide, TGF-beta superfamily, BMPR-II binding, Bone tissue engineering | KIPKASSVPTELSAISTLYL (H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH, linear 20-mer, free N/C termini) | C97H164N22O30 | 2117.20 | 2118.50 | TFA salt (typical) | 20 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-BMP2E-01 | White powder (BOC Sciences: White powder) | Store frozen below -20°C, protected from light, sealed and dry (BOC Sciences: Store at -20°C); avoid repeated freeze-thaw cycles | Store sealed and dry at 4°C, use within 2-4 weeks; aliquot and store reconstituted solution at -20°C | Good water solubility (net charge +1; enriched in hydrophilic Lys/Ser/Thr); reconstitute in water or buffer. No Cys/Met/Trp, no special oxidation- or light-sensitivity; prepare fresh and avoid prolonged storage in solution | powder is stable long-term (~3 years) sealed, dry and light-protected at -20°C; protect from moisture |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-BMP2E-01 | Synthetic peptide of the human BMP-2 mature-chain knuckle epitope (73-92), KIPKASSVPTELSAISTLYL, mimicking BMPR-II binding and osteogenic signaling for bone tissue engineering and osteogenesis research | This is a synthetic 20-mer of the knuckle epitope (residues 73-92) of human BMP-2 (a TGF-beta/BMP superfamily member), the segment that binds BMP receptor type II (BMPR-II). It mimics full-length BMP-2 to activate downstream Smad/osteogenic signaling, enhancing alkaline phosphatase (ALP) activity and osteogenic differentiation of mesenchymal stem cells (MSCs). Note: the UniProt P12643 precursor segment (residues 355-374) reads KIPKACCVPTELSAISMLYL, differing at 3 positions (Cys-Cys to Ser-Ser, Met to Thr) from the consensus commercial/literature sequence KIPKASSVPTELSAISTLYL used here, which is uniformly adopted by multiple independent studies and suppliers. The peptide is coated or grafted onto titanium alloys, hydroxyapatite and PEG hydrogel scaffolds to build osteoinductive materials for bone defect repair and spinal fusion research (Saito et al. BBA 2003; Jabbari et al. series). | Bone biology, Osteogenic differentiation, Bone tissue engineering, Mesenchymal stem cell research, Spinal fusion / bone defect repair materials | BMP receptor type II (BMPR-II); Smad osteogenic signaling pathway; MSC BMP receptor complex |
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