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| Product name CAS:295350‑45‑7 | Ozarelix |
| Description | Ozarelix is a third‑generation peptidergic gonadotropin‑releasing hormone (GnRH) receptor antagonist. It competitively binds to pituitary GnRH receptors, rapidly inhibits gonadotropin and sex hormone secretion, and has no initial agonist flare‑up response. Applied in mechanism research and drug development of prostate cancer, endometriosis and sex hormone‑dependent diseases. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical molecular weight (Da) | ~1417.60 (subject to actual batch) |
| Structure type | Multi D‑amino acid modified antagonist peptide |
Products Description
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Full Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Terminal Modification | Sequence Length (aa) |
| Ozarelix | Ozarelix; GnRH antagonist decapeptide; CAS 295350-45-7 | Pure GnRH receptor antagonism,No flare-up response,Rapid sex hormone inhibition,Prostate cancer study,Endometriosis research,Third-generation antagonist | Modified decapeptide backbone with multiple unnatural D-amino acids such as D-naphthylalanine and D-chlorophenylalanine | Large modified peptide, no precise small-molecule formula; subject to actual batch MS | - | ~1418 (theoretical) | N-terminal acetylation, C-terminal amidation | 10 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage Conditions | Short-term Storage Conditions | Liquid Stability | Solid Powder Stability |
| PEP-OZA001 | white powder | Store at -20℃, strictly protected from light, sealed and dry, aliquoted; avoid repeated freeze-thaw cycles | Solid powder stable for 2 years at 2-8℃ sealed and dry; stock solutions require small amount of DMSO for solubilization | Stable for 72 h at 4℃; stable for 1 month at -20℃ in aliquots. **Limited water solubility, small amount of DMSO or dilute acetic acid required for solubilization**. Multiple D-amino acids significantly enhance enzymatic resistance. Aromatic unnatural amino acids prone to photodegradation | Stable for 3 years at -20℃ under dry & dark conditions |
Functional Description
| Product Code | Frontend Short Summary (for search list display) | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-OZA001 | Third-generation pure antagonist GnRH decapeptide that rapidly inhibits sex hormone secretion with no initial agonist phase side effects | Ozarelix is a third-generation peptidergic GnRH receptor antagonist optimized through multiple structural modifications. Introduction of multiple D-type aromatic unnatural amino acids completely eliminates the receptor agonistic activity of native GnRH, making it a pure competitive antagonist. It directly binds to GnRH receptors on pituitary gonadotropin cell membranes, blocks the action of endogenous GnRH, rapidly inhibits secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and further reduces testosterone and estrogen levels. It does not have the initial hormone elevation (flare-up) reaction common to GnRH agonists, with faster onset and lower side effects. This molecule serves as a mechanism research tool for sex hormone-dependent diseases such as prostate cancer, endometriosis, uterine fibroids and precocious puberty, and also a core lead molecule for new-generation long-acting GnRH antagonist drug development. | Prostate cancer research,Endometriosis study,Sex hormone regulation research,GnRH pathway study,Reproductive endocrinology research,Peptide drug development | Gonadotropin-Releasing Hormone Receptor (GnRHR); Pituitary gonadotropin secretion inhibitory pathway; Sex hormone synthesis regulatory pathway |
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