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| Description | Lys-Gln-Ala-Gly-Asp-Val (KQAGDV, CAS: 80755-87-9) comprises the six most C-terminal amino acids of the human fibrinogen γ-chain (residues 406-411), molecular formula C₂₅H₄₄N₈O₁₀, MW 616.66 Da. It mediates cell adhesion through the α2bβ3 integrin and acts as a potent adhesion ligand for smooth muscle cells (SMCs); it corresponds to one of the platelet GPIIb/IIIa receptor recognition sequences on fibrinogen. KQAGDV is a valuable tool for studying platelet-fibrinogen binding, SMC adhesion, and integrin-mediated signaling in hemostasis, thrombosis, and cardiovascular research. |
| Structure type | Linear 6-mer (fibrinogen γ-chain 406-411) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| KQAGDV (Lys-Gln-Ala-Gly-Asp-Val; the minimal alphaIIb beta3-recognition hexapeptide from the C-terminus of the fibrinogen gamma chain) | KQAGDV; Lys-Gln-Ala-Gly-Asp-Val; H-Lys-Gln-Ala-Gly-Asp-Val-OH; C-terminal hexapeptide of the human fibrinogen gamma-chain HHL dodecapeptide (gamma400-411, HHLGGAKQAGDV); minimal alphaIIb beta3 (GPIIb/IIIa) recognition motif; fibrinogen-binding inhibitor; free acid; CAS 80755-87-9 | cell adhesion peptide, fibrinogen gamma chain, alphaIIb beta3 (GPIIb/IIIa) ligand, platelet aggregation inhibitor, antithrombotic peptide, thrombosis/platelet mechanism research, hemostasis and thrombosis, free acid | Linear hexapeptide, sequence Lys-Gln-Ala-Gly-Asp-Val (KQAGDV), H-Lys-Gln-Ala-Gly-Asp-Val-OH; free N-terminal amine and free C-terminal carboxyl (free acid, -COOH); near-neutral net charge (zwitterionic: 1 Lys - 1 Asp, N-terminus +, C-terminus -, ~0 at neutral pH); no Cys/Met/Trp (no disulfide/oxidation/photo-oxidation issues); the C-terminal hexapeptide of the human fibrinogen gamma-chain HHL dodecapeptide (residues gamma400-411, HHLGGAKQAGDV, the HHL fragment)-the minimal, non-RGD alphaIIb beta3 (GPIIb/IIIa) recognition motif; binds the conformationally activated GPIIb/IIIa on platelets via the gamma-chain C-terminus; supplied as the free acid (no counterion salt) | C25H44N8O10 | 616.32 | 616.67 | Free acid (C-terminal -COOH; no counterion salt); CAS 80755-87-9 | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-KQAGDV-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Met/Cys/Trp-low oxidation and photo-oxidation risk; the small-molecule lyophilate is chemically stable. The free acid form is only weakly hygroscopic. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Small zwitterionic peptide with good water solubility (mg/mL grade in pure water/aqueous buffer, near-neutral and readily soluble). No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation). The lyophilate is only weakly hygroscopic-routine sealing suffices. As a competitive inhibitor, prepare directly in buffer or in washed-platelet/plasma systems. Supplied as the free acid with no counterion, suitable for platelet and in-vivo studies; compare with RGD peptides and the full-length HHL dodecapeptide (HHLGGAKQAGDV) to dissect the gamma-chain non-RGD recognition of GPIIb/IIIa. | solid stable for ~2 years at -20°C, sealed and desiccated; routine desiccator storage is sufficient. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-KQAGDV-01 | The minimal alphaIIb beta3-recognition hexapeptide KQAGDV from the C-terminus of the fibrinogen gamma-chain HHL dodecapeptide; binds platelet integrin GPIIb/IIIa (alphaIIb beta3), competitively inhibits fibrinogen-platelet binding and suppresses platelet aggregation-used in thrombosis/platelet-aggregation mechanism research and antithrombotic peptide design. | KQAGDV is the C-terminal hexapeptide of the human fibrinogen gamma-chain HHL dodecapeptide (residues gamma400-411, HHLGGAKQAGDV, the HHL fragment)-the minimal, RGD-independent motif on fibrinogen that specifically recognizes platelet integrin GPIIb/IIIa (alphaIIb beta3). Upon platelet activation, GPIIb/IIIa adopts an open conformation and recognizes the fibrinogen gamma-chain C-terminus via its alphaIIb subunit (around residues 294-314), thereby bridging adjacent platelets and driving aggregation. As a soluble competitor, KQAGDV blocks fibrinogen binding to activated platelet GPIIb/IIIa and thereby inhibits platelet aggregation. Typical uses: (1) mechanistic studies of platelet aggregation and thrombus formation; (2) design and screening of antithrombotic/anti-GPIIb/IIIa peptides (e.g., along the eptifibatide direction); (3) distinguishing the RGD-dependent versus the gamma-chain non-RGD (KQAGDV) GPIIb/IIIa binding sites on fibrinogen; (4) studies of thrombus-targeted delivery (e.g., HHL dodecapeptide/liposomes targeting activated platelets). Supplied as the free acid with no counterion, water-soluble and chemically stable, ready for platelet and in-vivo work; note that as a short linear peptide its affinity is lower than engineered cyclic GPIIb/IIIa antagonists, so it is used mainly for mechanistic and competition experiments. | Platelet aggregation, thrombosis/hemostasis, antithrombotic peptide design, integrin alphaIIb beta3 biology, fibrinogen-platelet interactions, thrombus-targeted delivery | Platelet integrin GPIIb/IIIa (alphaIIb beta3, alphaIIb subunit around residues 294-314); competitively inhibits fibrinogen binding and platelet aggregation |
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