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| Description | The extreme N-terminus of MBP (residues 1–11, upstream of the canonical Ac1-9 immunodominant region), an autoantigen recognized in MS models; used for EAE induction, T-cell tolerance and pathogenesis. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Myelin Basic Protein (1-11), N-Acetyl Peptide | Ac-MBP(1-11); Ac-ASQKRPSQRHG; Acetyl-MBP; EAE autoantigen | Neuroimmunology, multiple sclerosis, myelin basic protein MBP, autoantigen, EAE model | Ac-ASQKRPSQRHG, N-acetylated linear 11-mer (C-term OH) | C52H88N22O17 | 1292.67 | 1293.41 | TFA salt (per supplier COA) | 11 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-MBP11-01 | White to off-white powder | Store at -20°C, dry and sealed | Short-term storage at 2-8°C | Basic peptide, readily soluble in water/slightly acidic buffer; prepare fresh solution, avoid repeated freeze-thaw | Stable as powder |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-MBP11-01 | The N-acetylated 11-mer Ac-ASQKRPSQRHG spanning residues 1-11 of human myelin basic protein, a key autoreactive T-cell epitope used in multiple sclerosis / EAE models. | Myelin basic protein (MBP) is a major component of the CNS myelin sheath and a principal autoantigen in human multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). The product under CAS 106128-98-7 is the N-terminally acetylated peptide Ac-ASQKRPSQRHG, covering human MBP residues 1-11 (position 10 = His, position 11 = Gly; the native MBP N-terminus is predominantly acetylated). It is recognized by autoreactive CD4+ T cells and drives myelin-directed immune attack, and is widely used to induce and study EAE, dissect MS autoimmune mechanisms, map T-cell epitopes and evaluate immunomodulatory therapies. | Neuroimmunology, multiple sclerosis (MS), EAE animal model, autoantigen T-cell epitopes, immunomodulatory drug evaluation | MBP-specific autoreactive CD4+ T cells; MBP(1-11) epitope presented by MHC class II |
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