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| Description | The hexapeptide ELDKWA, the minimal epitope of the broadly neutralizing gp41 membrane-proximal external-region antibody 2F5; used for bnAb epitope mapping and vaccine immunogen design. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| ELDKWA (HIV-1 gp41 membrane-proximal external region MPER hexapeptide) | ELDKWA, HIV-1 gp41 MPER epitope, EQELLELDKWASLWN, minimal epitope of antibody 2F5, H-Glu-Leu-Asp-Lys-Trp-Ala-OH | HIV-1 gp41 MPER epitope, 2F5 broadly neutralizing antibody, minimal epitope, HIV vaccine immunogen design, Trp-containing (light-protected), highly soluble short peptide | H-Glu-Leu-Asp-Lys-Trp-Ala-OH (ELDKWA, linear 6-mer, free N-terminal amino group and free C-terminal carboxyl; naturally embedded within gp41 sequence EQELLELDKWASLWN; contains 1 Trp, no Cys/Met) | C35H52N8O11 | 760.38 | 760.85 | Not specified (TargetMol lists as free acid; synthetic peptide typically TFA salt, per Certificate of Analysis) | 6 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-ELDKWA-01 | White solid powder | Store desiccated and sealed below -20°C, protected from light; powder stable for ~3 years; reconstituted aliquots can be stored at -80°C for ~1 year | Use short-term at 4°C sealed, desiccated and protected from light within 2-4 weeks; after reconstitution, aliquot and store at -20°C/-80°C, avoid repeated freeze-thaw | A short peptide with a high proportion of hydrophilic residues (Glu, Asp, Lys); readily water-soluble and can be reconstituted directly in water or PBS; contains 1 Trp susceptible to photo-oxidation, keep strictly protected from light; no Cys/Met, so no additional antioxidation/deoxygenation requirement | White solid powder, stable for ~3 years at -20°C when desiccated, light-protected and sealed; protect from moisture and light; aliquot promptly after opening and keep in a desiccator |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-ELDKWA-01 | The core hexapeptide epitope ELDKWA of the HIV-1 envelope glycoprotein gp41 membrane-proximal external region (MPER); the minimal epitope motif recognized by the broadly neutralizing antibody 2F5, used in HIV vaccine immunogen design and broadly neutralizing antibody research. | This peptide corresponds to the core hexapeptide motif ELDKWA of the HIV-1 transmembrane glycoprotein gp41 membrane-proximal external region (MPER), naturally embedded within the gp41 sequence EQELLELDKWASLWN. Literature shows ELDKWA is the minimal epitope core recognized by the human broadly neutralizing monoclonal antibody 2F5, which neutralizes diverse HIV-1 strains through recognition of this linear epitope. It is widely used in HIV vaccine immunogen design (MPER mimotope/conformational display), epitope mapping and affinity measurement of broadly neutralizing antibodies, and studies of antibody-peptide interaction mechanisms. Order by the sequence ELDKWA and CAS 152051-21-3. | HIV/AIDS vaccine research, gp41 MPER epitope mapping, broadly neutralizing antibodies, immunogen design, antibody-antigen interaction | Broadly neutralizing antibody 2F5 (anti-gp41 MPER); HIV-1 gp41 membrane-proximal external region epitope |
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