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| Description | Human γ-fibrinogen residues 377–395, involved in platelet integrin αIIbβ3 binding and autoimmune recognition; used for fibrinogen-platelet interactions and antiphospholipid/autoantibody epitopes. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| γ-Fibrinogen 377-395 (Human Fibrinogen γ-Chain Residues 377-395, 19-mer Mac-1-Binding Inhibitory Peptide; CAS 957792-67-5) | γ-Fibrinogen 377-395; Fibrinogen γ-chain 377-395; YSMKETTMKIIPFNRLSIG; PEP-FIBG377-01 | fibrinogen gamma-chain peptide, Mac-1 integrin blockade, CD11b/CD18, microglia inhibition, neuroinflammation, MS/EAE, coagulation-inflammation crosstalk, Met/Tyr light-sensitive | Linear 19-mer, H-Tyr-Ser-Met-Lys-Glu-Thr-Thr-Met-Lys-Ile-Ile-Pro-Phe-Asn-Arg-Leu-Ser-Ile-Gly-OH (YSMKETTMKIIPFNRLSIG), free acid (C-terminal -COOH); derived from residues 377-395 of human fibrinogen gamma chain (UniProt P02679), the near-C-terminal Mac-1(CD11b/CD18)-binding region; contains Met x2, Tyr x1, no Cys | C100H165N25O28S2 | 2228.17 | 2229.69 | TFA salt (confirmed by TargetMol; reported formula is the TFA-free peptide core) | 19 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-FIBG377-01 | White to off-white powder (TFA salt form) | Store at -20°C, sealed, desiccated and light-protected, ~2 years; contains Met x2 and Tyr x1, so protect from light and oxidants and from prolonged air exposure; aliquot to avoid repeated freeze-thaw. | 2-8°C, light-protected, for ~2 weeks; working aliquots at -20°C, light-protected; prepare fresh and avoid repeated freeze-thaw. | Amphipathic peptide (Lys/Glu hydrophilic vs Ile/Ile/Phe/Leu hydrophobic); soluble in water or pH 7.4 PBS, DMSO also aids solubilization; prepare 1-5 mg/mL stock and filter through 0.22 um. Because Met oxidizes and Tyr photo-oxidizes, keep solutions light-protected and away from oxidants; use at 4°C within ~1 week, store aliquoted at -20°C light-protected ~1-3 months; never repeatedly freeze-thaw. | No free Cys (no disulfide bond); solid stable ~2 years at -20°C, dry and light-protected. The TFA salt is hygroscopic: weigh quickly and reseal with desiccant; keep light-protected to preserve Met/Tyr side chains. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-FIBG377-01 | A 19-mer derived from residues 377-395 of human fibrinogen gamma chain (YSMKETTMKIIPFNRLSIG); blocks fibrin binding to integrin Mac-1 (CD11b/CD18) and inhibits microglial activation, for multiple sclerosis (EAE), neuroinflammation and blood-brain barrier studies. | Fibrinogen is converted to fibrin at the final stage of coagulation and deposits at sites of tissue injury; residues 377-395 near the C-terminus of its gamma chain (UniProt P02679) are the key region by which myeloid integrin Mac-1 (CD11b/CD18, CR3) recognizes deposited fibrin. gamma-Fibrinogen 377-395 (YSMKETTMKIIPFNRLSIG) acts as a competitive inhibitor, blocking the interaction of deposited fibrin with microglial Mac-1 and thereby suppressing excessive microglial activation and subsequent inflammatory demyelination. Intranasal administration of this peptide has been reported to improve motor function in experimental autoimmune encephalomyelitis (EAE) mice without affecting normal coagulation/hemostasis, indicating selective blockade of the "coagulation-inflammation" axis independent of hemostasis. Typical uses: competitive blockade of Mac-1/fibrin interactions, microglial activation mechanisms, blood-brain barrier and neuroinflammation models, and therapeutic target validation in multiple sclerosis (MS). | multiple sclerosis (EAE model), neuroinflammation, microglial activation, coagulation-inflammation crosstalk, Mac-1 (CD11b/CD18) integrin, blood-brain barrier | Integrin Mac-1 (CD11b/CD18, CR3) interaction with the fibrinogen gamma chain |
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