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| Description | REDV (CAS: 107978-83-6) is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) of human fibronectin, sequence Arg-Glu-Asp-Val, molecular formula C₂₀H₃₅N₇O₉, MW 517.53 Da. REDV mediates adhesion to the IIICS region by binding integrin α4β1 (VLA-4); it is used to study integrin-mediated cell adhesion, migration, and signaling, and is applied in vascular tissue engineering as an endothelial-cell-selective adhesion peptide. |
| Structure type | Linear 4-mer (fibronectin IIICS CS5 domain, VLA-4-binding) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| REDV (Arg-Glu-Asp-Val, fibronectin IIICS/CS5 endothelial-selective cell-adhesion tetrapeptide) | REDV; Arg-Glu-Asp-Val; R-E-D-V; Fibronectin CS5/IIICS cell-adhesion motif; minimal active sequence of the fibronectin alternatively-spliced IIICS region (CS5 site); CAS 107987-83-6; free acid | cell-adhesion peptide, extracellular matrix peptide, fibronectin, endothelial-selective, α4β1 (VLA-4) integrin ligand, vascular tissue engineering, vascular graft coating, endothelialization, anti-thrombogenic, free acid, hydrophilic | Linear 4-aa short cell-adhesion recognition peptide, sequence Arg-Glu-Asp-Val (R-E-D-V); the minimal active recognition motif within the CS5 site of the alternatively-spliced type III connecting segment (IIICS) of fibronectin; side-chain net charge ~-1 (Arg +1, Glu -1, Asp -1; ~-1 including N-terminus +1 and C-terminus -1); only Val is hydrophobic, the other three residues are charged/polar, giving an overall near-anionic, strongly hydrophilic short peptide; no Cys (no disulfide/thiol oxidation), no Met, no Trp; its endothelial selectivity does NOT come from RGD-type integrin binding but from an IIICS/CS5-conformation-dependent α4β1 (VLA-4) ligand; supplied as the free acid; CAS 107987-83-6 | C20H35N7O9 | 517.25 | 517.54 | Free acid; no counterion; CAS 107987-83-6 | 4 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-REDV-01 | White to off-white powder | Store at -20°C, sealed, desiccated, protected from light (~2 years). Aliquot to avoid repeated freeze-thaw. No Cys/Met/Trp-low oxidation/photo-oxidation risk; the short peptide is chemically stable. | 2–8°C for up to ~1 month; working aliquots at -20°C; stable for shipping at ambient. | Near-anionic, strongly hydrophilic short peptide; good water solubility-dissolves directly in water or standard aqueous buffers (PBS, HEPES, Tris), typically to several–tens of mg/mL, with sonication if needed. No Cys (no disulfide), no Met (no oxidation), no Trp (no photo-oxidation); highly stable across pH 4–8. For material coating, it is commonly immobilized onto scaffolds/grafts via N/C-terminal chemistry (amine-, carboxyl- or thiol-linker conjugation); soluble REDV is also used as a competitor in adhesion-inhibition assays. | solid stable for ~2 years at -20°C, sealed and desiccated; the short peptide is not strongly hygroscopic-keep in a desiccator. |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-REDV-01 | The REDV tetrapeptide from the fibronectin IIICS/CS5 site-an endothelial-selective α4β1 (VLA-4) integrin ligand that selectively supports endothelial cell adhesion while disfavoring smooth muscle cells, fibroblasts and platelets; a classic ECM-mimetic peptide for graft endothelialization and anti-thrombotic coatings. | REDV is the minimal active tetrapeptide of the fibronectin alternatively-spliced IIICS (CS5) region and an endothelial-selective integrin ligand: its primary receptor is integrin α4β1 (VLA-4), with reported co-operation of α5β1. The selectivity arises from receptor expression-α4β1 is prominently expressed on vascular endothelial cells (ECs) and endothelial progenitor cells (EPCs) as well as monocytes/leukocytes, but is absent/low on vascular smooth muscle cells (SMCs), fibroblasts and platelets. REDV coatings therefore selectively support EC adhesion, spreading and outside-in signaling (FAK/Src activation, downstream Ras-MAPK), driving rapid endothelialization, while relatively disfavoring SMC overgrowth (limiting neointimal hyperplasia) and not activating platelets (avoiding thrombosis). This 'pro-endothelial yet anti-thrombotic/anti-SMC' profile makes REDV a canonical coating peptide for small-diameter synthetic vascular grafts, stents and tissue-engineered vascular constructs, and it is also used for targeted gene/drug delivery to ECs/EPCs. It complements the broad-adhesion RGD/GRGDS peptides (which engage αvβ3, α5β1 and also adhere platelets and SMCs): REDV is chosen when endothelial selectivity is required. | Vascular tissue engineering, vascular graft/stent coatings, endothelialization, anti-thrombotic surfaces, neointimal hyperplasia inhibition, endothelial progenitor cell targeting, targeted drug/gene delivery, ECM-mimetic biomaterials, regenerative medicine | Integrin α4β1 (VLA-4, primary); co-operative α5β1; endothelial/EPC surface integrins; FAK/Src–Ras-MAPK adhesion signaling |
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