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| Description | YIGSR (CAS: 110590-64-2) is the active pentapeptide of laminin B1 chain residues 929-933, sequence Tyr-Ile-Gly-Ser-Arg, molecular formula C₂₆H₄₂N₈O₈, MW 594.66 Da. YIGSR specifically binds the 67-kDa laminin receptor, inhibits tumor growth and metastasis of leukemia cells, and regulates eNOS expression in endothelial cells; it is an important tool peptide in tumor-metastasis, vascular-biology, and basement-membrane function research. |
| Structure type | Linear 5-mer (laminin B1 chain 929-933) |
| Solubility | Readily soluble in water, PBS |
| Storage | Powder -20°C, dry, protected from light |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| YIGSR (Tyr-Ile-Gly-Ser-Arg, free acid) | YIGSR; Tyr-Ile-Gly-Ser-Arg-OH; laminin beta1 chain residues 929-933 (Laminin Fragment 929-933); receptor-binding site of laminin B1 chain domain III; ligand of the 67 kDa laminin receptor; 5-mer; CAS 110590-64-2 | laminin beta1-chain-derived peptide, 67 kDa laminin receptor (67LR/37LRP) ligand, non-integrin receptor, mediates cell adhesion, inhibits tumor growth and metastasis, anti-angiogenic, laminin-receptor binding site, 5-mer, free acid | Synthetic pentapeptide, sequence Tyr1-Ile2-Gly3-Ser4-Arg5 (YIGSR-OH); C-terminus is a free acid (-OH, not amidated), N-terminus is a free amine; no C-terminal amidation, no disulfide, no side-chain modification. It is a natural sequence on domain III of the laminin-111 (laminin-1) beta1 (B1) chain, corresponding to beta1-chain residues 929-933 (Laminin Fragment 929-933), and is the earliest-described and most-studied active short peptide from laminin. Its receptor is not an integrin but the non-integrin 37/67 kDa laminin receptor (67LR), formed by homodimerization and fatty-acid acylation of the 37LRP precursor. No Cys, Met, Trp, His or Pro. Charged residues: only Arg x1 (+1), with no Asp/Glu acidic residue; plus N-terminus (+1) and C-terminus (-1), net charge +1. It contains one hydrophobic Ile (plus the Tyr aromatic ring) but is overall hydrophilic and water-soluble (Sigma: 1 mg/mL in water gives a clear, colorless solution). | C26H42N8O8 | 594.31 | 594.67 | Free acid. Net charge +1 (Arg guanidinium + N-terminal amine, no acidic residue to balance); as supplied it is often isolated as a weak-acid (e.g., acetate) salt to balance charge; this product is calculated on the free-acid formula C26H42N8O8, consistent with Sigma-Aldrich (T7154) and TargetMol (TP2642) catalogs. | 5 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-YIGSR-01 | White to off-white powder | -20°C, dry and sealed; no Cys/Met/Trp so no oxidation/disulfide concern; aliquot and avoid repeated freeze-thaw | 2-8°C, dry, stable for several weeks | Small peptide with net charge +1 and good water solubility; dissolve directly in sterile water or neutral buffer (pH 6.5-7.4) (Sigma: clear colorless at 1 mg/mL in water), no DMSO needed; aliquot solutions at -20°C and avoid repeated freeze-thaw; avoid extreme pH and heat | The small peptide is stable as a solid with no oxidation/aggregation concern; store dry and sealed |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-YIGSR-01 | A natural pentapeptide from domain III of the laminin beta1 chain (Tyr-Ile-Gly-Ser-Arg-OH, residues 929-933); C-terminal free acid; formula C26H42N8O8, MW ~594.67. It binds the non-integrin 67 kDa laminin receptor (67LR, formed by dimerization/acylation of the 37LRP precursor), competes with laminin for the cell-surface receptor, and mediates/mimics laminin-cell adhesion; in vivo it blocks xenograft growth, experimental lung metastasis and leukemia cell dissemination, and inhibits angiogenesis. A classic tool peptide for laminin-receptor signaling, tumor invasion/metastasis, and 67LR-targeted delivery; water-soluble. | YIGSR is a natural pentapeptide on domain III of the laminin-111 beta1 (B1) chain, sequence Tyr-Ile-Gly-Ser-Arg-OH, corresponding to beta1-chain residues 929-933 (Laminin Fragment 929-933); it is the first described and most thoroughly studied active short peptide from laminin (over 240 publications). Its receptor is not an integrin but the non-integrin 37/67 kDa laminin receptor (37/67LR): the 37LRP (37 kDa laminin receptor precursor) homodimerizes and undergoes fatty-acid acylation to form the membrane-associated 67LR. YIGSR is the major laminin site that binds 67LR and can compete with native laminin for the cell-surface receptor, thereby mimicking/blocking laminin-cell adhesion. Biologically, 67LR is overexpressed in many tumor cells (melanoma, fibrosarcoma, breast, prostate, colon, pre-B acute lymphoblastic leukemia, etc.) and correlates with invasive/metastatic potential and chemoresistance; by occupying 67LR, YIGSR in vivo inhibits xenograft tumor growth, blocks experimental lung metastasis, reduces leukemia cell dissemination to organs, and suppresses angiogenesis. Unlike the alpha-chain-derived IKVAV (which promotes angiogenesis and metastasis), beta-chain-derived YIGSR impedes angiogenesis and tumor progression. Recent work also shows YIGSR modulates macrophage phenotype in a concentration-dependent manner. With no Cys/Met/Trp, good water solubility (Sigma: clear at 1 mg/mL in water), and no oxidation concern, YIGSR is a core tool peptide for studying laminin-receptor (67LR/37LRP) signaling, basement-membrane-cell interactions, tumor invasion/metastasis mechanisms, and 67LR-targeted drug delivery (e.g., YIGSR-conjugated nanoparticles/antibodies). | laminin-receptor interactions, 67 kDa laminin receptor (67LR/37LRP) signaling, tumor growth and metastasis inhibition, anti-angiogenesis, basement-membrane cell adhesion, tumor-targeted delivery (YIGSR conjugation), macrophage phenotype modulation, tumor-biology tool peptide | 67 kDa laminin receptor (67LR; 37LRP precursor dimerized/acylated), non-integrin laminin receptor, laminin beta1-chain receptor-binding site |
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