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| Description | PrP106-126 (KTNMKHMAGAAAAGAVVGGLG) is neurotoxic and amyloidogenic; this scrambled version shares composition but not order and lacks toxic aggregation, used to verify sequence-dependent toxicity. |
Product Basic Information Table
| Product Standard English Name | Product Abbreviation / Alias | Function Tags (comma-separated) | Core Structure | Molecular Formula | Exact Mass (Da) | Average MW (Da) | Salt Form | Length (aa) |
| Prion Protein (106-126) (human) (scrambled) | PrP 106-126 scrambled, scrambled negative control peptide, NGAKALMGGHGATKVMVGAAA, CAS 150469-23-1 | Prion/PrP,neurotoxic peptide,scrambled control,negative control,amyloid aggregation,CJD | NGAKALMGGHGATKVMVGAAA (H-Asn-Gly-Ala-Lys-Ala-Leu-Met-Gly-Gly-His-Gly-Ala-Thr-Lys-Val-Met-Val-Gly-Ala-Ala-Ala-OH, linear 21-mer; same amino-acid composition as wild-type KTNMKHMAGAAAAGAVVGGLG but shuffled) | C80H138N26O24S2 | 1910.98 | 1912.26 | Free acid (per published formula; CAS 150469-23-1; Bachem 4033124) | 21 |
Physicochemical Solubility & Storage Parameters
| Product Code | Appearance | Long-term Storage | Short-term Storage | Solution Stability | Solid Powder Stability |
| PEP-PRPS-01 | White to off-white powder (highly hydrophobic, purity >=95% HPLC; CAS 150469-23-1) | Store frozen below -20 C, dry, sealed and light-protected (single-use aliquots stable ~2-3 years; contains 2 Met, oxidation-prone) | Store at 4 C sealed and dry, use within 2-4 weeks; use reconstituted solution promptly, aliquot and store at -20 C | Poorly water-soluble (highly hydrophobic, 52% hydrophobic residues); first dissolve in DMSO or acetonitrile/HFIP, then dilute in PBS/buffer; aggregation-prone; keep reconstituted solution on ice, avoid repeated freeze-thaw; contains 2 Met (oxidation-prone), avoid oxidants | powder stable long-term (~2-3 years) at -20 C, dry, light-protected and sealed; moisture-proof; Met is oxidation-sensitive, avoid prolonged air exposure |
Functional Description
| Product Code | Frontend Short Summary | Detailed Biological Function Description | Applicable Research Areas (comma-separated) | Targets / Pathways |
| PEP-PRPS-01 | Prion Protein (106-126) (human) (scrambled) (NGAKALMGGHGATKVMVGAAA, CAS 150469-23-1) is the same-composition scrambled negative-control peptide of the neurotoxic human PrP 106-126 core fragment; its molecular weight is identical to wild-type KTNMKHMAGAAAAGAVVGGLG, used to rule out sequence-specific neurotoxicity and aggregation. | Wild-type human PrP 106-126 (KTNMKHMAGAAAAGAVVGGLG, CAS 148439-49-0) is a widely used neurotoxic core fragment in prion disease (CJD, scrapie, BSE) research that induces neuronal apoptosis, microglial activation, oxidative stress and beta-sheet amyloid aggregation. This product is the same-composition scrambled version (NGAKALMGGHGATKVMVGAAA, CAS 150469-23-1; Bachem product 4033124); its formula and MW are identical to wild-type (C80H138N26O24S2, avg 1912.26), but it lacks the sequence-specific neurotoxicity and aggregation propensity of WT. It is the standard negative-control peptide for PrP 106-126 neurotoxicity, aggregation kinetics and receptor-binding studies. | Prion diseases/CJD,neurodegeneration,amyloid aggregation,negative-control peptide,neurotoxicity model | PrP^C cell-surface receptor; neuronal membrane/oxidative-stress pathways (negative control; no sequence-specific neurotoxicity) |
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